For more than two decades, BioSpring has been manufacturing oligonucleotides for pre-clinical and clinical programs.

Benefit from our advanced manufacturing and analytical platforms.

We support your early-stage programs with small and intermediate-scale production and your late-stage and commercial programs with up to hundreds-of-kilograms API quantities.

BioSpring utilizes state-of-the-art technologies for oligonucleotide synthesis and downstream processing to ensure reproducible product quality. BioSpring was the first company to establish the next generation OligoProcess synthesizer within its highly efficient manufacturing platform.

Multiple clean rooms provide maximum flexibility for continuous and parallel manufacturing of cGMP-grade oligonucleotides.

Among the services that we offer for your preclinical and clinical oligonucleotide projects are:

• Process Development
• Scale-up, scale-down & process transfer
• Manufacturing capacities ranging from milligrams to hundreds-of-kilograms
• State-of-the-art technologies in oligonucleotide synthesis and downstream processing
• Dedicated cGMP compliant QC-laboratories for oligonucleotides
• Process validation & services
• Process characterization and DOE
• Cleaning validation

Benefit from our experience with a broad range of oligonucleotide classes:

• Antisense oligonucleotides (ASO)
• siRNAs
• miRNAs
• Aptamers
• CpG oligonucleotides
• sgRNA for CRISPR/Cas9 technology
• AntimiRs
• Catalytically-active oligonucleotides

Benefit from our experience with a broad range of oligonucleotide conjugates/modifications:

• GalNAc
• PEG
• Cholesterol
• Peptides
• Lipids
• Various base and sugar modifications
• Various backbone modifications