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Your GMP partner Nucleic Acid Manufacturing and Analysis Solutions
Leading the Future of Nucleic Acid Manufacturing And analysis

BioSpring Empowers Your Therapeutic Innovations

Customized Solutions for Nucleic Acid Manufacturing and Analysis – From Research to Commercial ApplicationsFDA_GMP.png

Welcome to BioSpring, your trusted partner for advancing nucleic acid-based therapies. With nearly three decades of experience, BioSpring is a dedicated nucleic acid CDMO specializing in in nucleic acid manufacturing and analytical services that support your drug development journey from preclinical research through to commercial production. Being FDA inspected and cGMP-certified, BioSpring is committed to the highest quality and regulatory standards. Our comprehensive services streamline your path to market, ensuring your therapies reach patients faster and more efficiently. Partner with BioSpring for robust, scalable solutions, tailored to each stage of your development pipeline. Let us bring your innovative therapies to life - together. 

1.pngEarly discovery through commercial cGMP therapeutic & diagnostic manufacturing

Synthesizer-icon.pngMultiple hundred kg annual manufacturing capacity, expansion to metric ton capacity until 2027

Gene-editing-icon.pngGlobal leader for the production of guide RNA for cell & gene therapy
(e.g. CRISPR/Cas)


 

Our Expertise:

 Our_expertise_.png
 
 
icon experts
Supporting six oligonucleotide commercial products and > 10 years of commercial experience
icon analytics
620 projects completed preclinical to commercial  since 2018
icon projectmanagement
> 100,000 oligonucleotides made  in the past 10 years 
For all stages of drug development

Comprehensive Manufacturing Services

At BioSpring, we provide end-to-end manufacturing solutions for nucleic acids, covering everything from small-scale research production to large-scale commercial batches. Our FDA-inspected, GMP-compliant facilities guarantee the highest quality, while our innovative technologies ensure your programs are prepared for every phase of clinical development. Whether you're working with siRNAs, ASOs, guide RNAs, or other nucleic acids, our tailored processes are designed to meet your exact needs. 

Covering the Entire Drug Development Lifecycle

 

Entire Drug Development Lifecycle new

Research & Discovery
  • Manufacturing for Research & Development, lead screening, and lead optimization
  • Custom manufacturing solutions and chemistries
  • High-throughput manufacturing
Preclinical
  • Early preclinical, mid-scale batch manufacturing
  • Regulatory tox batch manufacturing
  • Process development & scale-up
Clinical & Commercial
  • Commercial manufacturing and process validation
  • cGMP manufacturing for clinical phase I-III (ICH Q7)
  • Process transfer and optimization

Ensuring Precision and Compliance

Cutting-Edge Analytical Services

For Drug Substance & Drug Product

  • Release testing
  • Stability studies (ICH-compliant)
  • Raw material method transfer, development & validation 
  • Raw material analysis
  • In-house impurity marker synthesis
  • Analytical method transfer, development & validation
  • Stress tests/forced degradation studies
  • Reference standard characterization
  • In-process control analysis

 

 

From Research to market

 


The nucleic acid company

About BioSpring

BioSpring is a leading industry expert in nucleic acid science and technology, specializing in high-quality cGMP manufacturing and analytics for commercial programs and clinical phases I - III, in addition to preclinical material supply and diagnostic manufacturing. We are a privately owned company of over 650 employees committed to providing expert support through all phases and regulatory filings, including highly flexible and customizable solutions to accelerate therapeutic programs through the entire drug development lifecycle.

Headquartered in the center of Europe, in Frankfurt, Germany, we are an international company with a subsidiary in the United States and a local presence in Japan. Our global clients can rely on our quality and expertise, guided by our passion for innovation and three decades of experience. Our aim is a highly collaborative partnership to unleash the full potential of our clients’ technology, making great strides and breakthroughs possible. 

650 Employeesicon experts
40 Nations icon nations
Ideas icon ideas
 
 

Submit your inquiry

Ready to take your nucleic acid program to the next level? Contact BioSpring today to learn more about our comprehensive manufacturing and analytical services.

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