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Precision Medicine Starts Here Bioanalytical Services
Analytical services

Nucleic Acid Bioanalytical Services

Nucleic acid bioanalysis plays a pivotal role in the detection and quantification of nucleic acids within biological samples, ensuring the development of safe and effective therapies. It may also be used in the detection and identification of metabolites to better understand drug metabolism, bioavailability, and assess toxicity of a therapy.

Why BioSpring?

BioSpring offers comprehensive bioanalytical services for nucleic acids. We operate using a continuous improvement workflow to enhance quality, foster innovation, and reduce costs for our clients. Our expert bioanalytics team is ready to take on your project.

  • Broadest industry experience in oligonucleotide analytical methods
  • High flexibility & short setup time
  • In-house analytical methods optimized to achieve to the highest specificity and sensitivity
  • High confidence using latest mass-spectrometry techniques
  • Extensive internal R&D to continually optimize processes
  • No need to qualify additional suppliers
  • Established workflows from initial development and method setup

Your single-source provider for bioanalysis of ASOs, siRNAs, guide RNAs, mRNAs, and more!

Services Overview
  • Extraction of nucleic acids from various biofluids & tissues
  • Quantification by LC, LC-MS, LC-MS/MS, & hELISA in ng/mL range
  • Identification of metabolites from in vitro studies
  • ICH-compliant stability studies
  • Data support, pharmacokinetic & non-clinical investigations
Bioanalytical services

Pharmacokinetic Investigations

Assessing drug substance concentration in animal biofluids and tissues:

  • Plasma
  • Serum
  • Blood
  • Urine
  • CSF
  • Sputum
  • Nasal fluid
  • Liver
  • Heart
  • Kidney
  • Spleen
  • Lung
  • Lymphatic tissue

More available upon request.


Toxicity Studies

We offer the complete bioanalytical package to support your toxicity studies, starting with the development of sensitive methods for quantifying nucleic acids in biological samples. Next, we process animal tissue samples, carefully collecting, preserving, and analyzing the samples at our dedicated laboratories in Frankfurt, with close adherence to compliance and regulatory guidelines. As a last step, we conduct a systemic evaluation of the data using advanced statistical techniques, in coordination with selected partners, and generate reports for regulatory submissions.


Our Workflow

One source for all your bioanalytical needs.



Have a question or need a quote? Contact us


Learn more about our Analytical Services