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Custom IVT mRNA

A new era of medicine: Therapeutic mRNA revolutionizing treatment approaches

Since the mRNA vaccine race to market on the advent of COVID-19, a new generation of mRNA therapeutics has sparked interest in the biotechnology world. A favorable safety profile, efficacy, and low production time continues to inspire drug developers to explore mRNA therapies for a variety of therapeutic focuses. Messenger RNA (mRNA) is a carrier molecule which moves information encoded for a protein from a chromosome within a nucleus to the translation site in the cytoplasm. In the cytoplasm, ribosomes aid in the translation of mRNA into protein-encoding amino acids. mRNA’s capacity to employ a cell’s translational machinery positions it as a universal blueprint for protein production.


mRNA Manufacturing & Analytical Services

BioSpring is your single-source solution for custom in vitro transcription (IVT) mRNA production, offering comprehensive and integrated services for mRNA manufacturing, upscaling, and analytics. We are dedicated to providing comprehensive support spanning from the early discovery phase to preclinical programs. Stay tuned as we launch clinical and commercial GMP (ICH Q7) mRNA manufacturing capabilities later this year. 

We offer:

  • Fully customizable capping, poly(A) tail length, & modifications
  • Scalability: mRNA synthesis mg to gram scales (including long mRNA up to 7 kb or longer)
  • Large variety of nucleotide modifications to choose from
  • Manufacturing timelines of approximately 14 days (from receipt of DNA template)
  • In-house analytical services for mRNA analysis
  • Complete technical support from highly experienced teams, from inquiry through delivery

Our Capabilities July 2024

mRNA Capabilities

Manufacturing Workflow


Analytical Services

BioSpring is committed to ensuring that the mRNA you receive meets the highest quality standards. We have state-of-the-art equipment and highly experienced personnel who can analyze the integrity and purity of your mRNA to support you in the development of therapies. Our teams will perform all required release testing for your research or preclinical program in our dedicated laboratories.


Excerpt of R&D-grade release testing scope: 

  • Integrity by CE
  • Purity
  • Impurities
  • UV absorbance
  • mRNA concentration
  • Endotoxin (optional)